Evaluation of the fetal neuroprotection protocol using magnesium sulfate in a teaching university hospital in burkina faso

Abstract

Prematurity continues to stand as major public health issue worldwide and more particularly for low incomes countries like Burkina Faso. Indeed, it is the main cause of high death rate and infant morbidity, neurologic deficiencies being one of them.

Objective: Evaluate the fetal neuroprotection protocol through sulfates magnesium during births before thirty-three (33) weeks of amenorrhea, within University Health Centers of Yalgado Ouedraogo and Bogodogo in Ouagadougou, Burkina Faso, from March 1st to September 30th 2020.

Patients and Methods: It was a prospective cohort survey exposed/unexposed. Exposed ones come from UHC of Yalgado Ouedraogo and those unexposed from UHC of Bogodogo. Results: Analysis of the results showed 87 newborns from the exposed and 180 from the unexposed. Mortality rate as well as neonatal neurologic complications were higher with unexposed that with exposed. Although antenatal exposure to magnesium sulfate was not statistically associated with mortality and morbidity in newborns at a threshold of 0.05%, it has shown an overall good neurological prognosis in newborns exposed.

Conclusion: A survey on a large sample of population would be relevant in order to better assess the determinants of this influence.